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【英文标准名称】:StandardTestMethodforChronicOralToxicityStudyinRats
【原文标准名称】:老鼠口服慢性毒性研究的标准试验方法
【标准号】:ASTME1619-1995(2003)
【标准状态】:现行
【国别】:
【发布日期】:1995
【实施或试行日期】:
【发布单位】:美国材料与试验协会(US-ASTM)
【起草单位】:E47.02
【标准类型】:(TestMethod)
【标准水平】:()
【中文主题词】:血液;毒理学;毒性;老鼠;试验;农药
【英文主题词】:bloodchemistry;chronictoxicity;feedefficiency;gavage;hematology;LD;mecropsy;oral;pesticide;rat;toxicity;urinalysis
【摘要】:Thistestmethodshouldgeneratedatatoidentifythemajorityofchroniceffectsandshallservetodefinelong-termdoseresponserelationships.Inadditionthetestshouldallowforthedetectionofgeneraltoxiceffectsincludingneurological,physiological,biochemical,andhematologicaleffectsandexposure-relatedmorphological(pathology)effects.Thistestmethodshouldprovideinformationontargetorgans,thepossibilitiesofaccumulation,andmaybeusedforestablishingsafetycriteriaforhumanexposure.Itprovidesinformationonpotentialhealthhazardslikelytoarisefromrepeatedexposureoveralongperiodoftime.1.1Thistestmethodcoversalong-termstudytodeterminetheeffectsofasubstanceinamammalianspeciessuchastheratfollowingprolongedandrepeatedoralexposure.Undertheconditionsofthechronictoxicitytest,effectsthatrequirealonglatencyperiodorthatarecumulativeshouldbecomemanifest.1.2Thistestmethodassumesthattheuserisknowledgeableinmammaliantoxicologyandrelatedpertinentareas,andreliesheavilyonthejudgmentoftheevaluator.1.3ThevaluesstatedinSIunitsaretoberegardedasthestandard.Theinch-poundunitsgiveninparenthesesareforinformationonly.Thisstandarddoesnotpurporttoaddressallofthesafetyconcerns,ifany,associatedwithitsuse.Itistheresponsibilityoftheuserofthisstandardtoestablishappropriatesafetyandhealthpracticesanddeterminetheapplicabilityofregulatorylimitationspriortouse.Forspecifichazardstatements,seeSection6.
【中国标准分类号】:B42;C05
【国际标准分类号】:
【页数】:4P.;A4
【正文语种】: